Polynucleotides for the Face: What They Are and How These PDRN Injections Work
If you’ve heard about polynucleotides but aren’t sure how they differ from traditional skin biorevitalization, this article will help you understand.
What Are Polynucleotides?
Polynucleotides (PDRN) are DNA fragments derived from salmon. Their molecular structure is highly similar to human DNA, allowing them to effectively stimulate the skin’s natural regeneration processes while being well tolerated by the body.
It’s important to understand that polynucleotides are not dermal fillers or conventional hydrating treatments. While hyaluronic acid works primarily in the extracellular space by retaining moisture and providing temporary volume, PDRN penetrates deeper into the skin, supporting cellular regeneration from within.
How Does the Procedure Work?
Once injected into the skin, polynucleotides act as biostimulators. They activate skin cells and promote the production of collagen and elastin, helping to improve skin quality over time.
The results are gradual rather than immediate. Improvements develop throughout the treatment course and continue for several weeks after the final session.
A typical treatment plan includes 2–4 sessions spaced 2–4 weeks apart. Results generally last 6–12 months, with maintenance treatments recommended every 3–6 months.
What Results Can You Expect?
The outcome is subtle, natural-looking, and focused on improving skin quality rather than changing facial features. The skin appears healthier, smoother, more radiant, and more even in both texture and tone.
Unlike dermal fillers or neuromodulators, polynucleotides do not add volume, alter facial contours, or affect facial expressions. Instead, they support the skin’s own regenerative processes, resulting in gradual, natural rejuvenation.
Polynucleotide treatments are commonly recommended for:
- Dull, tired-looking skin
- Loss of firmness and elasticity
- Fine lines
- Post-acne marks
- Dehydrated skin
- Early signs of skin aging
- Preventive anti-aging care
Recovery After Treatment
Recovery is minimal. Small injection bumps (papules) may appear immediately after treatment and usually resolve within 1–2 days. Bruising is uncommon and, if it occurs, typically disappears within 3–5 days.
For several days after the procedure, patients are advised to avoid direct sun exposure, saunas, steam rooms, and intense physical exercise.
Is This Treatment Right for You?
If you’re considering polynucleotide injections and would like to know whether they’re suitable for your skin, schedule a consultation with a Medest cosmetic physician. After assessing your skin’s condition and discussing your goals, your specialist will recommend a personalized treatment plan tailored to your needs.